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Misuse potential (screen). Expanded danger of deadly respiratory despondency (esp. while starting treatment and during portion expands); screen. Incidental presentation may bring about lethal overdose (esp. youngsters). Rest related breathing problems (counting focal rest apnea (CSA), rest related hypoxemia); consider portion decrease if CSA creates. Danger of neonatal narcotic withdrawal condition. Pneumonic sickness (eg, COPD, cor pulmonale); screen for respiratory misery (esp. inside the initial 24–72hrs of starting treatment and after portion increments); consider elective non-narcotic analgesics. Head injury. Hindered awareness, trance state, stun; maintain a strategic distance from. Expanded intracranial weight, mind tumors; screen. Convulsive issues. Trouble gulping. Basic GI problems (eg, esophageal or colon malignancy with a little GI lumen). Biliary lot sickness. Intense pancreatitis. Intense liquor addiction. Medication victimizers. Stay away from unexpected suspension. Reexamine intermittently. Hindered renal or hepatic capacity. Older. Cachectic. Incapacitated. Pregnancy. Work and conveyance, nursing moms: not suggested.
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not that i know of.
there is a paradox here:
sex is the moment where you gradually loose control - until (eventually) orgasm.
playing a game is about being in control of an agent.
stripping the player of control is a bit like taking the game away from him/her.
other situation may have the player loose control and are explored already: fear, drugs, injury…
developing interactive scene with this paradox in mind is probably the key to memorable gaming.